Breathe and bloom: Gut hypoxia limits C. albicans growth

Animesh A Mishra; Andrew Y Koh

doi:10.1016/j.chom.2024.06.006

Breathe and bloom: Gut hypoxia limits C. albicans growth

Cell Host Microbe. 2024 Jul 10;32(7):1041-1043. doi: 10.1016/j.chom.2024.06.006.

Authors

Animesh A Mishra¹, Andrew Y Koh²

Affiliations

¹ Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
² Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: [email protected].

PMID: 38991499
DOI: 10.1016/j.chom.2024.06.006

Abstract

Multiple host and microbial factors dictate whether Candida albicans can colonize the mammalian gastrointestinal tract. In this issue of Cell Host & Microbe, Savage et al. demonstrate that restoration of intestinal epithelial hypoxia is sufficient to restore Candida albicans colonization resistance, even when other Candida inhibitory effectors remain depleted.

MeSH terms

Animals
Candida albicans* / growth & development
Candida albicans* / physiology
Candidiasis* / microbiology
Gastrointestinal Microbiome / physiology
Gastrointestinal Tract* / microbiology
Host-Pathogen Interactions
Humans
Hypoxia / metabolism
Intestinal Mucosa / metabolism
Intestinal Mucosa / microbiology
Mice