A composite reference standard is needed for bedaquiline antimicrobial susceptibility testing for Mycobacterium tuberculosis complex

Affiliations

• ¹ Department of Genetics, University of Cambridge, Cambridge, UK [email protected].
• ² Both authors contributed equally.
• ³ Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
• ⁴ South African Medical Research Council (SAMRC) Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
• ⁵ National Tuberculosis Reference Laboratory, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
• ⁶ Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.
• ⁷ German Center for Infection Research, Partner site Hamburg-Lübeck-Borstel-Riems, Germany.
• ⁸ Evolution of the Resistome, Research Center Borstel, Borstel, Germany.
• ⁹ National TB Reference Laboratory, National TB Control Program, Islamabad, Pakistan.
• ¹⁰ Unit of Mycobacteriology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
• ¹¹ Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
• ¹² Department of Microbiology, P.D. Hinduja Hospital and Medical Research Centre, Mumbai, India.
• ¹³ Centre for Tuberculosis, National TB Reference Laboratory, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.
• ¹⁴ Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
• ¹⁵ Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, USA.
• ¹⁶ Institute of Microbiology and Laboratory Medicine, Department IML red GmbH, WHO, Supranational Tuberculosis Reference Laboratory, Gauting, Germany.
• ¹⁷ SYNLAB Gauting, SYNLAB MVZ Dachau GmbH, Munich, Germany.
• ¹⁸ Department of Infectious Diseases, Region Östergötland, Linköping University Hospital, Linköping, Sweden.
• ¹⁹ Division of Infection and Inflammation, Institute of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
• ²⁰ Department of Infectious Diseases, Kalmar County Hospital, Linköping University, Kalmar, Sweden.