Necrostatin-1: a promising compound for neurological disorders

Front Cell Neurosci. 2024 Jun 27:18:1408364. doi: 10.3389/fncel.2024.1408364. eCollection 2024.

Abstract

Necrostatin-1, a small molecular alkaloid, was identified as an inhibitor of necroptosis in 2005. Investigating the fundamental mechanism of Necrostatin-1 and its role in various diseases is of great significance for scientific and clinical research. Accumulating evidence suggests that Necrostatin-1 plays a crucial role in numerous neurological disorders. This review aims to provide a comprehensive overview of the potential functions of Necrostatin-1 in various neurological disorders, offering valuable insights for future research.

Keywords: apoptosis; necroptosis; necrostatin-1; necrostatins; neurological disorders.

Publication types

  • Review

Grants and funding

The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.