Abstract
Three patients with widely disseminated Merkel cell tumors of the skin are presented. In all three cases, neuron-specific enolase (NSE) was demonstrated in neoplastic tissue by immunohistochemical staining, and serum NSE levels were also elevated in all three patients. Serum NSE may prove to be a useful tumor marker in this and other malignancies of neuroendocrine origin.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Female
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Histocytochemistry
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Humans
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Immunoenzyme Techniques
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Liver Neoplasms / enzymology
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Liver Neoplasms / secondary
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Lymph Node Excision
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Lymphatic Metastasis
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Male
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Middle Aged
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Neck Dissection
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Neoplasm Recurrence, Local / enzymology
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Phosphopyruvate Hydratase / blood*
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Radioimmunoassay
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Skin Neoplasms / enzymology*
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Skin Neoplasms / therapy
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Thoracic Neoplasms / enzymology
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Thoracic Neoplasms / secondary
Substances
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Phosphopyruvate Hydratase