Abstract
This study describes H2O2-activated photosensitizer nanoparticles (ICyHD NPs), which inhibit histone deacetylase via binding Zn2+ to induce ferroptosis and upregulate the intracellular O2, thus resulting in enhanced photodynamic therapeutic effect. ICyHD NPs exert strong antitumor effects on mice and have improved the therapeutic precision via observing the increase in cellular fluorescence.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Ferroptosis* / drug effects
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Humans
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Hydrogen Peroxide / pharmacology
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Mice
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Nanoparticles / chemistry
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Optical Imaging*
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Photochemotherapy*
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Photosensitizing Agents* / chemical synthesis
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Photosensitizing Agents* / chemistry
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Photosensitizing Agents* / pharmacology
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Tumor Microenvironment* / drug effects
Substances
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Photosensitizing Agents
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Antineoplastic Agents
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Hydrogen Peroxide