An AIE-active tetra-aryl imidazole-derived chemodosimeter for turn-on recognition of hydrazine and its bioimaging in living cells

Org Biomol Chem. 2024 Jul 31;22(30):6135-6140. doi: 10.1039/d4ob01009d.

Abstract

A new chemodosimeter SWJT-31 with an aggregation-induced emission (AIE) effect was designed and constructed. Upon increasing the water fraction in the solution, it exhibited typical AIE, which showed bright red fluorescence at 610 nm. SWJT-31 could sensitively and specifically recognize hydrazine by the TICT effect with an LOD of 33.8 nM, which was much lower than the standard of the USEPA. A portable test strip prepared using SWJT-31 was also developed for the visual detection of hydrazine. Eventually, it was successfully used for the detection of hydrazine in water samples and HeLa cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fluorescent Dyes* / chemical synthesis
  • Fluorescent Dyes* / chemistry
  • HeLa Cells
  • Humans
  • Hydrazines* / chemistry
  • Imidazoles* / chemical synthesis
  • Imidazoles* / chemistry
  • Molecular Structure
  • Optical Imaging

Substances

  • Hydrazines
  • hydrazine
  • Imidazoles
  • Fluorescent Dyes