Changing behind the scenes

Mandy J McGeachy

doi:10.1084/jem.20240840

Changing behind the scenes

J Exp Med. 2024 Aug 5;221(8):e20240840. doi: 10.1084/jem.20240840. Epub 2024 Jul 17.

Author

Mandy J McGeachy¹

Affiliation

¹ Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.

Abstract

Th17 cell plasticity is associated with pathogenicity in chronic inflammation. In a model of periodontitis, McClure et al. (https://doi.org/10.1084/jem.20232015) describe location-dependent divergence in Th17 plasticity, with surprisingly limited conversion in inflamed gingiva but emergence of protective exTh17-TfH cells in draining LN that enhance protective antibody.

MeSH terms

Animals
Cell Plasticity / immunology
Gingiva / immunology
Gingiva / pathology
Humans
Inflammation / immunology
Inflammation / pathology
Periodontitis / immunology
Periodontitis / pathology
Th17 Cells* / immunology