Acute inorganic nitrate ingestion does not impact oral microbial composition, cognitive function, or high-intensity exercise performance in female team-sport athletes

Eur J Appl Physiol. 2024 Dec;124(12):3511-3525. doi: 10.1007/s00421-024-05552-w. Epub 2024 Jul 17.

Abstract

The purpose of this study was to investigate the effects of acute nitrate (NO3-)-rich beetroot juice ingestion on explosive and high-intensity exercise performance, oral microbiota composition, and cognitive flexibility (i.e., function), before and after maximal intermittent running exercise. Fifteen women team-sport athletes were assigned in a randomized, double-blind, crossover design to consume concentrated NO3--depleted beetroot juice (PL; 0.1 mmol NO3-) and NO3--rich beetroot juice (BR; 12.0 mmol NO3-) 2.5 h prior to performing a battery of exercise performance tasks and cognitive testing before and after the Yo-Yo intermittent recovery level 1 (YYIR1) running test. Resting plasma [NO3-] and plasma nitrite ([NO2-]) were elevated following BR (P < 0.001). BR did not impact global composition or relative abundance of taxa in the oral microbiome (P > 0.05) or cognitive flexibility before or after exercise (P > 0.05). There was no significant difference in performance during 20-m (PRE, PL: 4.38 ± 0.27 vs. BR: 4.38 ± 0.32 s; POST, PL: 4.45 ± 0.29 vs. BR: 4.43 ± 0.35 s) and 10-m sprints (PRE, PL 2.78 ± 0.15 vs. BR 2.79 ± 0.18 s; POST, PL: 2.82 ± 0.16 vs. BR: 2.81 ± 0.19 s), isokinetic handgrip dynamometry, medicine ball throw, horizontal countermovement jump, or YYIR1 (PL: 355 ± 163 m vs. BR: 368 ± 184 m) between BR and PL (P > 0.05). These findings indicate that acute dietary NO3- may not influence the oral microbiome, explosive and high-intensity exercise performance, or cognitive function in women team-sport athletes.

Keywords: 16S rRNA sequencing; Beetroot; Exercise; Females; Nitric oxide; Strength.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Athletes*
  • Athletic Performance* / physiology
  • Beta vulgaris
  • Cognition* / drug effects
  • Cross-Over Studies
  • Double-Blind Method
  • Exercise / physiology
  • Female
  • Fruit and Vegetable Juices
  • Humans
  • Microbiota / drug effects
  • Mouth / microbiology
  • Nitrates* / blood
  • Running / physiology
  • Young Adult

Substances

  • Nitrates