Advancements in manganese complex-based MRI agents: Innovations, design strategies, and future directions

Drug Discov Today. 2024 Sep;29(9):104101. doi: 10.1016/j.drudis.2024.104101. Epub 2024 Jul 15.

Abstract

This review focuses on the advancements in manganese (Mn) complex-based magnetic resonance imaging (MRI) agents for imaging different diseases. Here we emphasize the unique redox properties of Mn to deliver innovative MRI contrast agents, including small molecules, nanoparticles (NPs), metal-organic frameworks (MOFs), and polymer hybrids. Aspects of their rational design have been discussed, including size dependence, morphology tuning, surface property enhancement, etc., while also discussing the existing challenges and potential solutions. The present work will inspire and motivate scientists to emphasize MRI-guided applications and bring clinical success in the coming years.

Keywords: Mn complexes; contrast agents; imaging; magnetic resonance imaging; nanomedicines.

Publication types

  • Review

MeSH terms

  • Animals
  • Contrast Media* / chemistry
  • Drug Design
  • Humans
  • Magnetic Resonance Imaging* / methods
  • Manganese* / chemistry
  • Metal-Organic Frameworks / chemistry
  • Nanoparticles
  • Polymers / chemistry

Substances

  • Contrast Media
  • Manganese
  • Metal-Organic Frameworks
  • Polymers