Targeting TRPM channels for cerebral ischemia-reperfusion injury

Trends Pharmacol Sci. 2024 Oct;45(10):862-867. doi: 10.1016/j.tips.2024.06.005. Epub 2024 Jul 16.

Abstract

Transient receptor potential melastatin (TRPM) channels have emerged as potential therapeutic targets for cerebral ischemia-reperfusion (I/R) injury. We highlight recent findings on the involvement of TRPM channels in oxidative stress, mitochondrial dysfunction, inflammation, and calcium overload. We also discuss the challenges and future directions in targeting TRPM channels for cerebral I/R injury.

Keywords: TRPM channels; calcium overload; cerebral ischemia–reperfusion injury; inflammatory responses; mitochondrial dysfunction; oxidative stress.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain Ischemia / drug therapy
  • Brain Ischemia / metabolism
  • Calcium / metabolism
  • Humans
  • Mitochondria / metabolism
  • Oxidative Stress*
  • Reperfusion Injury* / metabolism
  • TRPM Cation Channels* / antagonists & inhibitors
  • TRPM Cation Channels* / metabolism

Substances

  • TRPM Cation Channels
  • Calcium