Dental pulp stem cells - A basic research and future application in regenerative medicine

Katarzyna Stefańska; Ana Angelova Volponi; Magdalena Kulus; Jadwiga Waśko; Maryam Farzaneh; Joanna Grzelak; Shirin Azizidoost; Paul Mozdziak; Dorota Bukowska; Paweł Antosik; Maciej Zabel; Marzenna Podhorska-Okołów; Piotr Dzięgiel; Marta Szcześniak; Maria Woszczyk; Bartosz Kempisty

doi:10.1016/j.biopha.2024.116990

Dental pulp stem cells - A basic research and future application in regenerative medicine

Biomed Pharmacother. 2024 Sep:178:116990. doi: 10.1016/j.biopha.2024.116990. Epub 2024 Jul 17.

Authors

Katarzyna Stefańska¹, Ana Angelova Volponi², Magdalena Kulus³, Jadwiga Waśko⁴, Maryam Farzaneh⁵, Joanna Grzelak⁶, Shirin Azizidoost⁷, Paul Mozdziak⁸, Dorota Bukowska⁹, Paweł Antosik¹⁰, Maciej Zabel¹¹, Marzenna Podhorska-Okołów¹², Piotr Dzięgiel¹³, Marta Szcześniak¹⁴, Maria Woszczyk¹⁵, Bartosz Kempisty¹⁶

Affiliations

¹ Cellivia 3 S.A., Poznan 60-529, Poland; Department of Histology and Embryology, Poznan University of Medical Sciences, Poznan 60-781, Poland. Electronic address: [email protected].
² Centre for Craniofacial and Regenerative Biology, Dental Institute, King's College London, London WC2R 2LS, UK. Electronic address: [email protected].
³ Department of Veterinary Surgery, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, Torun 87-100, Poland. Electronic address: [email protected].
⁴ Cellivia 3 S.A., Poznan 60-529, Poland.
⁵ Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address: [email protected].
⁶ Division of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, Wroclaw 50-368, Poland. Electronic address: [email protected].
⁷ Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address: [email protected].
⁸ Prestage Department of Poultry Sciences, North Carolina State University, Raleigh, NC 27695, USA. Electronic address: [email protected].
⁹ Department of Diagnostics and Clinical Sciences, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, Torun 87-100, Poland. Electronic address: [email protected].
¹⁰ Department of Veterinary Surgery, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, Torun 87-100, Poland. Electronic address: [email protected].
¹¹ Division of Histology and Embryology, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, Wroclaw 50-368, Poland; Division of Anatomy and Histology, University of Zielona Góra, Zielona Góra 65-046, Poland. Electronic address: [email protected].
¹² Division of Ultrastructural Research, Department of Human Morphology and Embryology, Wroclaw Medical University, Wroclaw 50-368, Poland. Electronic address: [email protected].
¹³ Division of Histology and Embryology, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, Wroclaw 50-368, Poland. Electronic address: [email protected].
¹⁴ Department of Diagnostics, Poznan University of Medical Sciences, Bukowska 70, Poznań 60-812, Poland; Department of Maxillofacial Surgery, Poznan University of Medical Sciences, Przybyszewskiego 49, Poznań 60-355, Poland. Electronic address: [email protected].
¹⁵ WSPL SP ZOZ; ul. Szylinga 1, Poznań, Poland. Electronic address: [email protected].
¹⁶ Department of Veterinary Surgery, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, Torun 87-100, Poland; Division of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, Wroclaw 50-368, Poland; College of Agriculture and Life Sciences, North Carolina State University, Raleigh, NC 27695, USA; Center of Assisted Reproduction, Department of Obstetrics and Gynecology, University Hospital and Masaryk University, Brno, Czech Republic.

PMID: 39024839
DOI: 10.1016/j.biopha.2024.116990

Abstract

Dental pulp is a valuable and accessible source of stem cells (DPSCs) with characteristics similar to mesenchymal stem cells. DPSCs can regenerate a range of tissues and their potential for clinical application in regenerative medicine is promising. DPSCs have been found to express low levels of Class II HLA-DR (MHC) molecules, making them potential candidates for allogeneic transplantation without matching the donor's tissue. Research on the correlation between non-coding RNAs (ncRNAs) and human dental pulp stem cells (DPSCs) provides promising insights into the use of these cells in clinical settings for a wide range of medical conditions. It is possible to use a number of ncRNAs in order to restore the functional role of downregulated ncRNAs that are correlated with osteoblastogenesis, or to suppress the functional role of overexpressed ncRNAs associated with osteoclast differentiation in some cases.

Keywords: Dental pulp; Non-coding RNAs; Signaling pathways; Stem cells.

Publication types

Review

MeSH terms

Animals
Cell Differentiation
Dental Pulp* / cytology
Humans
RNA, Untranslated / genetics
Regenerative Medicine* / methods
Stem Cell Transplantation / methods
Stem Cells* / cytology
Stem Cells* / metabolism

Substances

RNA, Untranslated