Extranodal marginal zone lymphoma of the larynx: A case report and scoping review

Head Neck. 2024 Dec;46(12):3056-3065. doi: 10.1002/hed.27863. Epub 2024 Jul 19.

Abstract

Background: This scoping review aims to review cases of extranodal marginal zone lymphoma (MZL) of the larynx to establish best management practices for this rare clinical entity.

Methods: In this paper, we report a case of laryngeal MZL, in accordance with CARE guidelines. We then performed a scoping review according to PRISMA-ScR criteria of published cases of MZL involving the larynx. The following data were collected for each case: age, sex, size, location(s) involved, stage, treatment, follow-up, and recurrence duration.

Results: Sixty-six patients with laryngeal MZL, first reported in 1990, were identified. Characterized by its low-grade histological appearance and indolent course, laryngeal MZL is generally confined to the larynx and has an excellent prognosis with radiation used as first-line therapy.

Conclusions: It is imperative for clinicians to consider lymphoma in the differential diagnosis of a laryngeal tumor from any subsite, as certain pathologies may carry high risks of metastasis.

Keywords: extranodal non‐Hodgkin lymphoma; head and neck cancer; laryngeal lymphoma; mucosa‐associated lymphoid tissue lymphoma.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Female
  • Humans
  • Laryngeal Neoplasms* / pathology
  • Laryngeal Neoplasms* / therapy
  • Lymphoma, B-Cell, Marginal Zone* / pathology
  • Lymphoma, B-Cell, Marginal Zone* / therapy
  • Male
  • Middle Aged