Dry Crusty Nose: Not Just Rhinosinusitis! Hidden IgG4-related Disease Without IgG4 Level Rise

J Community Hosp Intern Med Perspect. 2024 May 7;14(3):113-118. doi: 10.55729/2000-9666.1335. eCollection 2024.

Abstract

IgG4-related disease (IgG4-RD) is a fibro-inflammatory condition that can affect various organs. Localized sinonasal IgG4-RD is a rare condition characterized by bone and soft-tissue invasion. In this report, we present a case of a patient initially diagnosed with chronic rhinosinusitis, who underwent endoscopic sinus surgery and was later found to have biopsy proven IgG4-related sinonasal disease despite having normal serum levels of IgG4, resulting in erosion of the right lamina papyracea.

Keywords: Chronic rhinosinusitis; Endoscopic sinus surgery; Fibro-inflammatory condition; IgG4-related disease (IgG4-RD); Lamina papyracea; Localized sinonasal IgG4-RD; Soft-tissue invasion.

Publication types

  • Case Reports