Assessing the effect of COVida orphans and vulnerable children support services on viral load coverage and suppression among children and adolescents living with HIV in four provinces in Mozambique

AIDS Care. 2024 Aug;36(8):1190-1198. doi: 10.1080/09540121.2024.2373400. Epub 2024 Jul 24.

Abstract

Orphans and vulnerable children (OVC) programs focusing on improving HIV outcomes for children and adolescents living with HIV (C&ALHIV) may improve viral load (VL) testing coverage, a critical step toward achieving VL suppression. In Mozambique, we conducted a retrospective medical record review comparing VL testing coverage and suppression between C&ALHIV receiving OVC support and two cohorts of non-participants constructed using propensity score matching. We collected data for 25,783 C&ALHIV in Inhambane, Maputo City, Nampula, and Tete between October 2020-September 2021. Unadjusted rates of VL testing were 62.9% among OVC participants compared with 39.2% and 50.4% of non-participants in OVC support and non-OVC support districts, respectively. In multivariate models, OVC participants were 18 and 10 percentage points more likely to have received a VL test than non-participants in OVC districts (p < 0.01) and non-OVC districts (p < 0.01), respectively. OVC participants under 5 years old were significantly more likely to have received a VL test than their same-age counterparts in both comparison groups. Overall, the OVC program did not demonstrate significant effects on VL suppression. This approach could be replicated in other contexts to improve testing coverage. It is crucial that clinical partners and governments continue to share data to enable timely monitoring through OVC programming.

Keywords: ART adherence; Mozambique; Orphans and vulnerable children; SDG 3: Good health and well-being; children and adolescents living with HIV; viral load suppression; viral load testing coverage.

MeSH terms

  • Adolescent
  • Anti-HIV Agents / therapeutic use
  • COVID-19 / epidemiology
  • Child
  • Child, Orphaned* / statistics & numerical data
  • Child, Preschool
  • Female
  • HIV Infections*
  • Humans
  • Infant
  • Male
  • Mozambique / epidemiology
  • Retrospective Studies
  • SARS-CoV-2
  • Viral Load*
  • Vulnerable Populations*

Substances

  • Anti-HIV Agents