A transgenic mouse model of Down syndrome acute lymphoblastic leukemia identifies targetable vulnerabilities

Jacob J Junco; Max Rochette; Michelle Alozie; Raushan Rashid; Maci Terrell; Barry Zorman; Pavel Sumazin; Lauren Rowland; Gino Dettorre; Reid T Powell; Clifford C Stephan; Peter J Davies; Margarita Martinez-Moczygemba; Jun J Yang; Karen R Rabin

doi:10.3324/haematol.2023.284761

A transgenic mouse model of Down syndrome acute lymphoblastic leukemia identifies targetable vulnerabilities

Haematologica. 2024 Dec 1;109(12):4083-4088. doi: 10.3324/haematol.2023.284761.

Authors

Affiliations

¹ Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX. [email protected].
² Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX.
³ Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.
⁴ Institute of Biosciences and Technology, Texas A-M University, Houston, TX, USA; Department of Translational Medical Sciences, School of Medicine, Texas A-M University, Houston, TX.
⁵ Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX. [email protected].

No abstract available

Grants and funding

Funding: This research was supported by a Scholar Award from the American Society of Hematology (to JJJ), the Elsa U. Pardee Foundation (to JJJ), funding from the NIH (P30 CA125123-12 and R01 CA249867) (to KRR), grant RP170074 from the Cancer Prevention and Research Institute of Texas (CPRIT) (to KRR), the Lynch family (to KRR), the Dan L. Duncan Comprehensive Cancer Center, and the John S. Dunn Gulf Coast Consortium for Chemical Genomics. This project was supported by the Cytometry and Cell Sorting Core at Baylor College of Medicine with funding from the CPRIT Core Facility Support Award (CPRIT-RP180672), the NIH (CA125123 and RR024574), and the assistance of Joel M. Sederstrom. This project was supported by the Center for Translational Cancer Research at Texas A&M University with funding from CPRIT grants RP200668 and RP190581.