Assessment of luminescent copper nanomaterials as anti-germs, anti-proliferation efficiencies using green nano-strategy

Luminescence. 2024 Jul;39(7):e4831. doi: 10.1002/bio.4831.

Abstract

For the first time, we suggest using leaf extract from Ocimum americanum as the economically viable bio-fabrication of copper nanomaterials. The residuals of leaf extract bio-capping provide the stability of the nanomaterials in-situ. UV-Vis and XRD confirmed the formation, with the UV-Vis spectrum of Cu-NMs revealing a surface plasmon resonance characteristic peak at 350 nm. FT-IR analysis was employed to examine the functional groups. FE-SEM with EDX was used to assess the morphology and carry out an elemental analysis of the nanomaterials. Diffusion and MTT assays were used to study the antimicrobial and anticancer activities. The synthesized copper nanomaterials exhibited in-vitro cytotoxicity against human skin cancer (A431) cell lines. Green nanomaterial was examined against the methylene blue dye, photodegradation was reduced by up to 90.6% within 50 minutes. The copper nanomaterials synthesized in our study exhibit promising applications in biomedicine and environmental pollution research.

Keywords: Photodegradation; anti‐germs; anti‐proliferation; cu NMs; green synthesis – Ocimum americanum.

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Cell Proliferation* / drug effects
  • Copper* / chemistry
  • Copper* / pharmacology
  • Drug Screening Assays, Antitumor
  • Green Chemistry Technology
  • Humans
  • Luminescence
  • Luminescent Agents / chemical synthesis
  • Luminescent Agents / chemistry
  • Luminescent Agents / pharmacology
  • Metal Nanoparticles / chemistry
  • Microbial Sensitivity Tests
  • Nanostructures / chemistry
  • Particle Size
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Leaves / chemistry

Substances

  • Copper
  • Antineoplastic Agents
  • Plant Extracts
  • Anti-Bacterial Agents
  • Luminescent Agents