Splicing regulation of DNA repair via CCAR1

Yuxi Ai; Omar Abdel-Wahab

doi:10.1016/j.molcel.2024.06.012

Splicing regulation of DNA repair via CCAR1

Mol Cell. 2024 Jul 25;84(14):2591-2592. doi: 10.1016/j.molcel.2024.06.012.

Authors

Yuxi Ai¹, Omar Abdel-Wahab²

Affiliations

¹ Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
² Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: [email protected].

PMID: 39059366
DOI: 10.1016/j.molcel.2024.06.012

Abstract

In this issue of Molecular Cell, Harada et al.¹ and Karasu et al.² identify CCAR1 as a novel regulator of the Fanconi anemia/BRCA DNA repair pathway via modulating the splicing of the mRNA encoding FANCA.

Publication types

Comment

MeSH terms

BRCA1 Protein / genetics
BRCA1 Protein / metabolism
DNA Repair*
Fanconi Anemia / genetics
Fanconi Anemia / metabolism
Fanconi Anemia Complementation Group A Protein / genetics
Fanconi Anemia Complementation Group A Protein / metabolism
Humans
RNA Splicing*
RNA, Messenger / genetics
RNA, Messenger / metabolism

Substances

Fanconi Anemia Complementation Group A Protein
RNA, Messenger
BRCA1 Protein