STING: Stay near to STIM(1) neuroprotection

Hong-Gyun Lee; Francisco J Quintana

doi:10.1016/j.molcel.2024.06.034

STING: Stay near to STIM(1) neuroprotection

Mol Cell. 2024 Jul 25;84(14):2596-2597. doi: 10.1016/j.molcel.2024.06.034.

Authors

Hong-Gyun Lee¹, Francisco J Quintana²

Affiliations

¹ Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
² Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Gene Lay Institute of Immunology and Inflammation, Boston, MA, USA. Electronic address: [email protected].

PMID: 39059368
DOI: 10.1016/j.molcel.2024.06.034

Abstract

In a recent publication in Cell, Woo et al.¹ report that stimulator of interferon genes (STING) links inflammation with glutamate-driven excitotoxicity to induce ferroptosis, identifying a mechanism of inflammation-induced neurodegeneration and also a novel candidate therapeutic target for multiple sclerosis.

Publication types

Comment

MeSH terms

Animals
Ferroptosis* / drug effects
Ferroptosis* / genetics
Glutamic Acid / metabolism
Humans
Inflammation
Membrane Proteins* / genetics
Membrane Proteins* / metabolism
Multiple Sclerosis* / drug therapy
Multiple Sclerosis* / genetics
Multiple Sclerosis* / immunology
Multiple Sclerosis* / metabolism
Neuroprotection*
Signal Transduction
Stromal Interaction Molecule 1 / genetics
Stromal Interaction Molecule 1 / metabolism

Substances

Membrane Proteins
STING1 protein, human
Stromal Interaction Molecule 1
Glutamic Acid