General Capillary Endothelial Cells Undergo Reprogramming Into Arterial Endothelial Cells in Pulmonary Hypertension Through HIF-2α/Notch4 Pathway

Bin Liu; Dan Yi; Xiaomei Xia; Karina Ramirez; Hanqiu Zhao; Yanhong Cao; Ankit Tripathi; Ryan Dong; Anton Gao; Hongxu Ding; Shenfeng Qiu; Vladimir V Kalinichenko; You-Yang Zhao; Michael B Fallon; Zhiyu Dai

doi:10.1161/CIRCULATIONAHA.123.067981

General Capillary Endothelial Cells Undergo Reprogramming Into Arterial Endothelial Cells in Pulmonary Hypertension Through HIF-2α/Notch4 Pathway

Circulation. 2024 Jul 30;150(5):414-417. doi: 10.1161/CIRCULATIONAHA.123.067981. Epub 2024 Jul 29.

Authors

Bin Liu^{1

2

3}, Dan Yi^{1

2

3}, Xiaomei Xia^{1

2}, Karina Ramirez^{1

2}, Hanqiu Zhao^{1

2}, Yanhong Cao^{1

2}, Ankit Tripathi^{1

2}, Ryan Dong^{1

2}, Anton Gao^{1

2}, Hongxu Ding⁴, Shenfeng Qiu⁵, Vladimir V Kalinichenko^{6

7}, You-Yang Zhao^{8

9}, Michael B Fallon², Zhiyu Dai^{1

2

3

10

11}

Affiliations

¹ Division of Pulmonary, Critical Care and Sleep (B.L., D.Y., X.X., K.R., H.Z., Y.C., A.T., R.D., A.G., Z.D.), College of Medicine-Phoenix, University of Arizona.
² Department of Internal Medicine (B.L., D.Y., X.X., K.R., H.Z., Y.C., A.T., R.D., A.G., M.B.F., Z.D.), College of Medicine-Phoenix, University of Arizona.
³ Translational Cardiovascular Research Center (B.L., D.Y., Z.D.), College of Medicine-Phoenix, University of Arizona.
⁴ Department of Pharmacy Practice & Science, College of Pharmacy (H.D.), University of Arizona, Tucson.
⁵ Department of Basic Medical Science (S.Q.), College of Medicine-Phoenix, University of Arizona.
⁶ Phoenix Children's Health Research Institute (V.V.K.), College of Medicine-Phoenix, University of Arizona.
⁷ Division of Neonatology, Phoenix Children's Hospital, AZ (V.V.K.).
⁸ Program for Lung and Vascular Biology and Section for Injury Repair and Regeneration Research, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, IL (Y-Y.Z.).
⁹ Department of Pediatrics, Division of Critical Care, Northwestern University Feinberg School of Medicine, Chicago, IL (Y-Y.Z.).
¹⁰ BIO5 Institute (Z.D.), University of Arizona, Tucson.
¹¹ Sarver Heart Center (Z.D.), University of Arizona, Tucson.

PMID: 39074180
PMCID: PMC11296501 (available on 2025-07-30)
DOI: 10.1161/CIRCULATIONAHA.123.067981

No abstract available

Keywords: PAH; angiogenesis; endothelium; lung vasculature; right heart failure.

Publication types

Letter

MeSH terms

Animals
Basic Helix-Loop-Helix Transcription Factors* / genetics
Basic Helix-Loop-Helix Transcription Factors* / metabolism
Capillaries / metabolism
Capillaries / pathology
Cellular Reprogramming
Endothelial Cells* / metabolism
Endothelial Cells* / pathology
Humans
Hypertension, Pulmonary* / metabolism
Hypertension, Pulmonary* / pathology
Mice
Pulmonary Artery / cytology
Pulmonary Artery / metabolism
Pulmonary Artery / pathology
Receptor, Notch4* / genetics
Receptor, Notch4* / metabolism
Signal Transduction*

Substances

Basic Helix-Loop-Helix Transcription Factors
endothelial PAS domain-containing protein 1
Receptor, Notch4

Publication types

MeSH terms

Substances

Grants and funding