Correlation of PSA blood levels with standard uptake value maximum (SUV max ) and total metabolic tumor volume (TMTV) in 18F-PSMA-1007 and 18F-choline PET/CT in patients with biochemically recurrent prostate cancer

Nucl Med Commun. 2024 Nov 1;45(11):924-930. doi: 10.1097/MNM.0000000000001881. Epub 2024 Jul 30.

Abstract

Objectives: In this prospective study, we investigated the correlation between prostate-specific antigen (PSA) levels in the blood of patients with prostate cancer in biochemical recurrence after radical treatment with the semiquantitative parameters standard uptake value maximum (SUV max ) and the total metabolic tumor volume (TMTV) in the metastatic foci depicted in 18F-prostate-specific membrane antigen (PSMA)-1007 and 18F-choline PET/computed tomography (CT) imaging.

Methods: We prospectively examined 104 patients with biochemical relapse of prostate cancer after primary definitive treatment. All patients underwent one 18F-PSMA-1007 and one 18F-choline PET/CT examination in randomized order within a time frame of 10 days and were followed for at least 6 months (182 ± 10 days). The semiquantitative parameters of SUV max and metabolic tumor volume (MTV) of each neoplastic lesion in PET/CT imaging were calculated, and further summation of each MTV value was done to calculate the TMTV.

Results: According to the Spearman correlation analysis, a positive correlation was found between PSA levels and SUV max and TMTV scores in the metastatic foci of 18F-PSMA-1007 PET/CT ( r = 0.24 and 0.35, respectively; P < 0.05) and SUV max in the lesions of 18F-choline PET/CT ( r = 0.28; P < 0.0239). However, a positive but NS correlation was demonstrated between values of PSA and TMTV for each lesion in the 18F-choline PET/CT study ( r = 0.22; P = 0.0795). The detection rate of the different PSA levels with a cutoff of 1 ng/ml was higher for 18F-PSMA-1007 than 18F-choline.

Conclusion: In biochemical relapse patients there is a positive correlation between PSA levels in the blood and the semiquantitative parameters SUV max and TMTV of the metastatic foci in the 18F-PSMA-1007 and 18F-Choline PET/CT imaging.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biological Transport
  • Choline* / analogs & derivatives
  • Fluorine Radioisotopes
  • Humans
  • Male
  • Middle Aged
  • Niacinamide / analogs & derivatives
  • Oligopeptides
  • Positron Emission Tomography Computed Tomography*
  • Prospective Studies
  • Prostate-Specific Antigen* / blood
  • Prostatic Neoplasms* / blood
  • Prostatic Neoplasms* / diagnostic imaging
  • Prostatic Neoplasms* / metabolism
  • Prostatic Neoplasms* / pathology
  • Recurrence
  • Tumor Burden*

Substances

  • Choline
  • Prostate-Specific Antigen
  • PSMA-1007
  • Niacinamide
  • Fluorine Radioisotopes
  • Oligopeptides
  • Fluorine-18
  • fluoromethylcholine