Pregnancy in Congenital Adrenal Hyperplasia

Nicole Reisch; Richard J Auchus

doi:10.1016/j.ecl.2024.05.005

Pregnancy in Congenital Adrenal Hyperplasia

Endocrinol Metab Clin North Am. 2024 Sep;53(3):391-407. doi: 10.1016/j.ecl.2024.05.005. Epub 2024 Jun 25.

Authors

Nicole Reisch¹, Richard J Auchus²

Affiliations

¹ Department of Medicine IV, Institute for Endocrinology, Diabetology & Metabolism, Klinikum der Universität München, Ziemssenstraße 1, München 80336, Germany.
² Department of Pharmacology, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, MSRB II, 5560A, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, MSRB II, 5560A, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: [email protected].

PMID: 39084815
DOI: 10.1016/j.ecl.2024.05.005

Abstract

Over the last several decades, children with all forms of classic congenital adrenal hyperplasia (CAH) are identified early and treated appropriately throughout childhood. As adults, women with CAH may desire to become mothers and their usual chronic therapy and disease control is often inadequate for conception. Subsequently, little data exist on their management during pregnancy. Pregnancy in women with various forms of CAH is possible with appropriate treatment. Achieving pregnancy is more complex than disease management during pregnancy.

Keywords: Congenital adrenal hyperplasia; Estrogen; Glucocorticoids; Ovulation induction; Pregnancy; Progesterone.

Publication types

Review

MeSH terms

Adrenal Hyperplasia, Congenital* / diagnosis
Adrenal Hyperplasia, Congenital* / therapy
Female
Humans
Pregnancy
Pregnancy Complications* / therapy