Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib

Leukemia. 2024 Sep;38(9):2046-2050. doi: 10.1038/s41375-024-02353-0. Epub 2024 Jul 31.

Ariel Leyte-Vidal^{1

2}, RosaAnna DeFilippis¹, Ian R Outhwaite³, Isabelle Kwan^{3

4

5}, Ji Young Lee⁴, Carlyn Leavitt¹, Kaeli B Miller¹, Delphine Rea⁶, Aziz M Rangwala³, Kevin Lou^{7

8}, Suhana Patel¹, Ailin Alvarez¹, Kevan M Shokat^{7

8

9}, Ivet Bahar^{4

5}, Markus A Seeliger^{3

4}, Neil P Shah¹⁰

¹ Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA.
² Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, 33101, USA.
³ Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.
⁴ Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, 11794, USA.
⁵ Department of Biochemistry and Cell Biology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.
⁶ Adult Hematology Department, Hôpital Saint-Louis, Paris, France.
⁷ Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, 94158, USA.
⁸ Howard Hughes Medical Institute, University of California, San Francisco, CA, 94158, USA.
⁹ Department of Chemistry, University of California, Berkeley, CA, 94720, USA.
¹⁰ Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA. [email protected].

No abstract available

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