Acute liver failure: A clinically severe syndrome characterized by intricate mechanisms

World J Hepatol. 2024 Jul 27;16(7):1067-1069. doi: 10.4254/wjh.v16.i7.1067.

Abstract

Acute liver failure presents as a clinical syndrome characterized by swift deterioration and significant mortality rates. Its underlying mechanisms are intricate, involving intricate interplays between various cells. Given the current scarcity of treatment options, there's a pressing need to diligently uncover the disease's core mechanisms and administer targeted therapies accordingly.

Keywords: Acute liver failure; Ferroptosis; Hepatocyte; Macrophage; Necroptosis; Pyroptosis.