Exploring the hidden mental health consequences of malaria beyond the fever

Front Hum Neurosci. 2024 Jul 18:18:1432441. doi: 10.3389/fnhum.2024.1432441. eCollection 2024.

Abstract

Malaria morbidity has various presentations and the focus now shifts to uncommon signs and symptoms of malaria infection such as cognitive impairment to address the morbidity when the mortality declines. About 50% of children admitted to hospitals due to malaria experience neurological complications due to factors like low blood sugar, inflammation, elevated pressure, decreased oxygen levels, and excitotoxicity. Malaria during pregnancy negatively also impacts children's cognitive, behavioral, and executive function leading to neurodevelopmental delay due to increased susceptibility which can significantly affect maternal and child health, leading to higher rates of underestimated factors like anxiety, depression, and PTSD. Despite having the world's second-largest tribal population, India's indigenous and tribal communities and their mental health are less explored and less understood. Western psychological tools and neurocognitive assessment tools are not universally applicable, thus necessitating the development of tailored tools to investigate psychological or neurocognitive impairment. This paper has illuminated the hidden mental health consequences of malaria infection, emphasizing the prevalence, nature, and implications of psychological distress among affected individuals. The findings underscore the importance of recognizing and addressing these psychological consequences in the holistic management and prevention of malaria and its mental health consequences.

Keywords: cerebral malaria; cognitive impairment; malaria; malaria morbidity; mental health; neurocognition; neurological impairment.

Publication types

  • Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by Grant-in-aid Scheme of the Department of Health Research for ‘Inter-Sectoral Convergence & Coordination for Promotion and Guidance on Health Research-approval’ to the research project entitled “Assessment of impact of malaria disease on cognitive and executive functions among the adult malaria patients in Mangaluru - cohort study” covered under the component Mental Health to ‘Research Studies With Emphasis on Public Health’ of the aforesaid scheme and the “Longitudinal community evaluation of survivorship, biological efficacy, fabric integrity and community acceptability of long-lasting insecticidal net MiraNet in comparison with Magnet LN® as positive control in India” project funded by Ifakara Health Institute, Tanzania.