Successful Treatment of Refractory Cutaneous Protothecosis With MAT2203, an Oral Lipid Nanocrystal Formulation of Amphotericin B

Open Forum Infect Dis. 2024 Jul 18;11(8):ofae428. doi: 10.1093/ofid/ofae428. eCollection 2024 Aug.

Abstract

Prototheca wickerhamii is a rare cause of cutaneous and systemic infection that requires long treatment courses with potentially toxic medications. We describe a patient with cutaneous protothecosis refractory to triazole monotherapy who experienced clinical and radiographic improvement with the novel oral lipid nanocrystal formulation of amphotericin B without experiencing toxicity.

Keywords: MAT2203; Prototheca; amphotericin; cutaneous infection; novel antifungals.

Publication types

  • Case Reports