Intrasinusoidal bone marrow involvement in mantle cell lymphoma: a case series with review of the main differential diagnoses

Arturo Bonometti; Alexander Tzankov; Ilaria Alborelli; Norman F Russkamp; Susanne Dertinger; Stefan Dirnhofer

doi:10.1007/s00428-024-03885-7

Intrasinusoidal bone marrow involvement in mantle cell lymphoma: a case series with review of the main differential diagnoses

Virchows Arch. 2024 Aug 6. doi: 10.1007/s00428-024-03885-7. Online ahead of print.

Authors

Arturo Bonometti^{1

2}, Alexander Tzankov³, Ilaria Alborelli⁴, Norman F Russkamp^{5

6}, Susanne Dertinger⁷, Stefan Dirnhofer³

Affiliations

¹ Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20090, Milan, Italy. [email protected].
² Pathology Unit, Humanitas Clinical and Research Hospital, Via Manzoni 56, Rozzano, 20089, Milan, Italy. [email protected].
³ Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
⁴ Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
⁵ Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
⁶ Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland.
⁷ Institute of Pathology, Academic Teaching Hospital Feldkirch, Feldkirch, Austria.

PMID: 39107523
DOI: 10.1007/s00428-024-03885-7

Abstract

Intrasinusoidal bone marrow involvement is an infrequent histological pattern observed in a limited number of B and T cell lymphomas. Mantle cell lymphoma is a biologically and prognostically heterogeneous B cell lymphoma that frequently involves the bone marrow, with interstitial, nodular-paratrabecular, or diffuse patterns. Intrasinusoidal bone marrow involvement has been described only anecdotally in this lymphoma. Here, we describe the clinical, histopathological, and molecular features of four patients diagnosed with advanced-stage mantle cell lymphoma, showing intrasinusoidal bone marrow involvement, and other peculiar immunophenotypical features. As similar cases may represent a relevant issue in bone marrow diagnostic histopathology, we also reviewed the literature to discuss differential diagnoses of B and T cell lymphomas with intrasinusoidal bone marrow involvement.

Keywords: Bone marrow lymphomas; Differential diagnosis; Hematopathology; Mantle cell lymphoma.