The roles of E2F7 in cancer: Current knowledge and future prospects

Ke-Qian Chen; Hai-Bo Lei; Xiang Liu; Shu-Zhi Wang

doi:10.1016/j.heliyon.2024.e34362

The roles of E2F7 in cancer: Current knowledge and future prospects

Heliyon. 2024 Jul 9;10(14):e34362. doi: 10.1016/j.heliyon.2024.e34362. eCollection 2024 Jul 30.

Authors

Ke-Qian Chen^{1

2}, Hai-Bo Lei¹, Xiang Liu¹, Shu-Zhi Wang²

Affiliations

¹ Department of Clinical Pharmacy, Xiangtan Central Hospital, Xiangtan, 411100, China.
² Institute of Pharmacy and Pharmacology, School of Pharmaceutical Sciences, Hengyang Medical School, University of South China, Hengyang, 421001, China.

Abstract

Background: E2F7 is a recently discovered member of the E2F family. Investigating the function and mechanism of E2F7 in the growth of tumors is significant for the clinical diagnosis and therapy of these malignancies.

Objective: The purpose of this review is to provide theoretical basis for the diagnosis and treatment of malignant tumors by exploring E2F7.

Methods: The relevant information was collected through the PubMed database using keyword searches "E2F7" and "cancer".

Results: On the one hand, E2F7 plays an essential role in embryonic development, angiogenesis, and the nervous system. On the other hand, E2F7 is also linked to the occurrence and growth of various malignant tumors.

Conclusion: E2F7 has potential as a therapeutic target in future cancer treatments.

Keywords: Biological function; Cancer; DNA damage; E2F7; Transcription.

Publication types

Review