Wells syndrome following vaccination: A pediatric case with positive patch test to gelatin

Bárbara Vieira Granja; Maria João Cruz; Pedro Rolo De Matos; Ana Paula Cunha; Pedro Amoroso Canão; Teresa Baudrier; Alberto Mota

doi:10.1111/pde.15719

Wells syndrome following vaccination: A pediatric case with positive patch test to gelatin

Pediatr Dermatol. 2024 Aug 7. doi: 10.1111/pde.15719. Online ahead of print.

Authors

Bárbara Vieira Granja^{1

2}, Maria João Cruz^{1

3}, Pedro Rolo De Matos¹, Ana Paula Cunha^{1

3}, Pedro Amoroso Canão⁴, Teresa Baudrier¹, Alberto Mota^{1

5}

Affiliations

¹ Department of Dermatology and Venereology, Centro Hospitalar Universitário de São João, Porto, Portugal.
² Department of Biomedicine, Faculty of Medicine, Porto University, Porto, Portugal.
³ Faculty of Medicine, Porto University, Porto, Portugal.
⁴ Department of Pathology, Centro Hospitalar Universitário de São João, Porto, Portugal.
⁵ RISE@CINTESIS, Faculty of Medicine, Porto University, Porto, Portugal.

PMID: 39112433
DOI: 10.1111/pde.15719

Abstract

We report a 12-month-old boy with a skin eruption that developed 15 days after receiving the measles, mumps, rubella (MMR), pneumococcal, and meningococcal vaccines, consistent with the diagnosis of Wells syndrome. Patch testing showed a positive reaction to gelatin, which is used as a stabilizer for both live and inactivated vaccines. Gelatin was only present in the MMR vaccine.

Keywords: gelatin; pediatric eosinophilic cellulitis; pediatric wells syndrome; vaccine reaction.

Publication types

Case Reports