Intraoperative surgical navigation as a precision medicine tool in sinonasal and craniofacial oncologic surgery

Oral Oncol. 2024 Oct:157:106979. doi: 10.1016/j.oraloncology.2024.106979. Epub 2024 Aug 8.

Abstract

Introduction: Recent evidence supports the efficacy of surgical navigation (SN) in improving outcomes of sinonasal and craniofacial oncologic surgery. This study aims to demonstrate the utility of SN as a tool for integrating surgical, radiologic, and pathologic information. Additionally, a system for recording and mapping biopsy samples has been devised to facilitate sharing of spatial information.

Materials and methods: SN was utilized for biopsy mapping in 10 sinonasal/craniofacial oncologic procedures. Twenty-five raters with experience in anterior skull base oncology were interviewed to identify 15 anatomical structures in preoperative imaging, relying on topographical descriptions and surgical video clips. The difference in the localization of anatomical structures by raters was analyzed, using the SN-mapped coordinates as a reference (this difference was defined as spatial error).

Results: The analysis revealed an average spatial error of 9.0 mm (95 % confidence interval: 8.3-9.6 mm), with significant differences between surgeons and radiation oncologists (7.9 mm vs 12.5 mm, respectively, p < 0.0001). The proposed model for transferring SN-mapped coordinates can serve as a tool for consultation in multidisciplinary discussions and radiotherapy planning.

Conclusions: The current standard method to evaluate disease extension and margin status is associated with a spatial error approaching 1 cm, which could affect treatment precision and outcomes. The study emphasizes the potential of SN in increasing spatial precision and information sharing. Further research is needed to incorporate this method into a multidisciplinary workflow and measure its impact on outcomes.

Keywords: Computer-assisted; Head and neck cancer; Head and neck neoplasms; Precision medicine; Skull base; Surgery.

MeSH terms

  • Biopsy / methods
  • Female
  • Humans
  • Male
  • Middle Aged
  • Paranasal Sinus Neoplasms / pathology
  • Paranasal Sinus Neoplasms / surgery
  • Precision Medicine* / methods
  • Surgery, Computer-Assisted* / methods