Insights into the structure of RNPs from segmented negative-sense RNA viruses

Samantha Hover; John N Barr; Juan Fontana

doi:10.1016/j.str.2024.07.008

Insights into the structure of RNPs from segmented negative-sense RNA viruses

Structure. 2024 Aug 8;32(8):1027-1028. doi: 10.1016/j.str.2024.07.008.

Authors

Samantha Hover¹, John N Barr², Juan Fontana³

Affiliations

¹ School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK. Electronic address: [email protected].
² School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK. Electronic address: [email protected].
³ School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK. Electronic address: [email protected].

PMID: 39121836
DOI: 10.1016/j.str.2024.07.008

Abstract

The genome of segmented negative-sense single-stranded RNA viruses, such as influenza virus and bunyaviruses, is coated by viral nucleoproteins (NPs), forming a ribonucleoprotein (RNP). In this issue of Structure, Dick et al.¹ expand our knowledge on the RNPs of these viruses by solving the structures of Thogoto virus NP and RNP.

MeSH terms

Models, Molecular
Nucleoproteins / chemistry
Nucleoproteins / metabolism
RNA Viruses / genetics
RNA, Viral / chemistry
RNA, Viral / genetics
RNA, Viral / metabolism
Ribonucleoproteins* / chemistry
Ribonucleoproteins* / metabolism
Thogotovirus / chemistry
Thogotovirus / metabolism
Viral Proteins / chemistry
Viral Proteins / genetics
Viral Proteins / metabolism

Substances

Ribonucleoproteins
RNA, Viral
Viral Proteins
Nucleoproteins

Grants and funding

MR/X020916/1/MRC_/Medical Research Council/United Kingdom