Natural product pharmacology: the British Journal of Pharmacology perspective

Xin Wang; Angelo A Izzo; Andreas Papapetropoulos; Steve P H Alexander; Miriam Cortese-Krott; Dave A Kendall; Kirill A Martemyanov; Claudio Mauro; Reynold A Panettieri Jr; Hemal H Patel; Rainer Schulz; Barbara Stefanska; Gary J Stephens; Mauro M Teixeira; Nathalie Vergnolle; Péter Ferdinandy

doi:10.1111/bph.17300

Natural product pharmacology: the British Journal of Pharmacology perspective

Br J Pharmacol. 2024 Oct;181(19):3547-3555. doi: 10.1111/bph.17300. Epub 2024 Aug 11.

Authors

Xin Wang¹, Angelo A Izzo², Andreas Papapetropoulos^{3

4}, Steve P H Alexander⁵, Miriam Cortese-Krott^{6

7}, Dave A Kendall⁵, Kirill A Martemyanov⁸, Claudio Mauro⁹, Reynold A Panettieri Jr¹⁰, Hemal H Patel¹¹, Rainer Schulz¹², Barbara Stefanska¹³, Gary J Stephens¹⁴, Mauro M Teixeira¹⁵, Nathalie Vergnolle¹⁶, Péter Ferdinandy^{17

18}

Affiliations

¹ Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
² Department of Pharmacy, University of Naples Federico II, Naples, Italy.
³ Laboratory of Pharmacology, Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.
⁴ Clinical Experimental Surgery and Translational Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
⁵ University of Nottingham, Nottingham, UK.
⁶ Myocardial Infarction Research Laboratory, Department of Cardiology, Pneumology, Angiology, Medical Faculty, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
⁷ CARID, Cardiovascular Research Institute Düsseldorf, Düsseldorf, Germany.
⁸ Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, Florida, USA.
⁹ Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
¹⁰ Rutgers University, New Brunswick, New Jersey, USA.
¹¹ VA San Diego Healthcare System and University of California/San Diego, San Diego, California, USA.
¹² University of Giessen, Giessen, Germany.
¹³ University of British Columbia, Vancouver, British Columbia, Canada.
¹⁴ University of Reading, Reading, UK.
¹⁵ Federal University of Minas Gerais, Belo Horizonte, Brazil.
¹⁶ IRSD, Université de Toulouse, INSERM, INRAE, ENVT, UPS, Toulouse, France.
¹⁷ Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.
¹⁸ Pharmahungary Group, Szeged, Hungary.

PMID: 39128855
DOI: 10.1111/bph.17300

Abstract

Natural products (NPs) have long been used as a rich source of bioactive compounds for drug development. Recent technological advancements have revitalised natural products research as evidenced by increased publications in this field. In this editorial review, we highlight key points from the 2020 British Journal of Pharmacology (BJP) practical guide, which outlines standards for natural products research reports, and provide papers published in BJP between years 2020 to 2023 that demonstrate adherence to these guidelines. Looking ahead, we discuss the potential of chemical proteomics approaches to elucidate natural products mechanisms of action and identify therapeutic targets for future research. By fostering innovation, we aim to advance natural products research and contribute to the development of novel therapeutics that will have a significant impact on healthcare.

Keywords: chemical proteomics; drug discovery; natural products.

Publication types

Review

MeSH terms

Animals
Biological Products* / chemistry
Biological Products* / pharmacology
Drug Development
Humans
Periodicals as Topic
Pharmacology
Proteomics

Substances

Biological Products