Auto tandem triple cascade organocatalysis: access to bis-lactone and butenolide derivatives

Stéphane Wittmann; Elodie Deschamps; Chloée Bournaud; Regis Guillot; Jean-François Brière; Giang Vo-Thanh; Martial Toffano

doi:10.1039/d4cc03029j

Auto tandem triple cascade organocatalysis: access to bis-lactone and butenolide derivatives

Chem Commun (Camb). 2024 Aug 22;60(69):9278-9281. doi: 10.1039/d4cc03029j.

Authors

Stéphane Wittmann¹, Elodie Deschamps¹, Chloée Bournaud¹, Regis Guillot¹, Jean-François Brière², Giang Vo-Thanh¹, Martial Toffano¹

Affiliations

¹ Institut de Chimie Moléculaire et des Matériaux d'Orsay, CNRS-UMR-8182, Université Paris-Saclay, Bât. H. Moissan. 19 avenue des sciences, 91400 Orsay, France.
² Normandie Univ, UNIROUEN, INSA Rouen, CNRS, COBRA, 76000 Rouen, France.

PMID: 39129442
DOI: 10.1039/d4cc03029j

Abstract

The synthesis of bis-lactone and butenolide derivatives was described using alkylidene Meldrum's acid as nucleophiles. The process operates in a triple cascade through an auto tandem catalysis promoted by DBU.