Management of triple-negative breast cancer by natural compounds through different mechanistic pathways

Mohammed Kaleem; Mandar Thool; Nitin G Dumore; Abdulrasheed O Abdulrahman; Wasim Ahmad; Amal Almostadi; Mohammad Hassan Alhashmi; Mohammad Amjad Kamal; Shams Tabrez

doi:10.3389/fgene.2024.1440430

Management of triple-negative breast cancer by natural compounds through different mechanistic pathways

Front Genet. 2024 Jul 26:15:1440430. doi: 10.3389/fgene.2024.1440430. eCollection 2024.

Authors

Mohammed Kaleem¹, Mandar Thool², Nitin G Dumore¹, Abdulrasheed O Abdulrahman³, Wasim Ahmad⁴, Amal Almostadi⁵, Mohammad Hassan Alhashmi^{5

6}, Mohammad Amjad Kamal^{5

7

8

9

10}, Shams Tabrez^{5

6}

Affiliations

¹ Department of Pharmacology, Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India.
² Department of Pharmaceutics, Dadasaheb Balpande College of Pharmacy, Nagpur, Maharashtra, India.
³ Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
⁴ Department of KuliyateTib, National Institute of Unani Medicine, Bengaluru, India.
⁵ King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
⁶ Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
⁷ Center for High Altitude Medicine, Institutes for Systems Genetics, West China School of Nursing, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
⁸ Department of Pharmacy, Faculty of Health and Life Sciences, Daffodil International University, Birulia, Bangladesh.
⁹ Centre for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.
¹⁰ Enzymoics, Hebersham, NSW, Australia; Novel Global Community Educational Foundation, Hebersham, NSW, Australia.

Abstract

Triple-negative breast cancer (TNBC) is the most severe form of breast cancer, characterized by the loss of estrogen, progesterone, and human epidermal growth factor receptors. It is caused by various genetic and epigenetic factors, resulting in poor prognosis. Epigenetic changes, such as DNA methylation and histone modification, are the leading mechanisms responsible for TNBC progression and metastasis. This review comprehensively covers the various subtypes of TNBC and their epigenetic causes. In addition, the genetic association of TNBC with all significant genes and signaling pathways linked to the progression of this form of cancer has been enlisted. Furthermore, the possible uses of natural compounds through different mechanistic pathways have also been discussed in detail for the successful management of TNBC.

Keywords: DNA methylation; TNBC; epigenetic mechanims; genes; histone modification; natural drugs.

Publication types

Review

Grants and funding

The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.