Satellite cell dynamics during skeletal muscle hypertrophy

Biochem Soc Trans. 2024 Aug 28;52(4):1921-1926. doi: 10.1042/BST20240201.

Abstract

Skeletal muscle stem cells (MuSCs) display distinct behavior crucial for tissue maintenance and repair. Upon activation, MuSCs exhibit distinct modes of division: symmetric division, facilitating either self-renewal or differentiation, and asymmetric division, which dictates divergent cellular fates. This review explores the nuanced dynamics of MuSC division and the molecular mechanisms governing this behavior. Furthermore, it introduces a novel phenomenon observed in a subset of MuSCs under hypertrophic stimuli termed division-independent differentiation. Insights into the underlying mechanisms driving this process are discussed, alongside its broader implications for muscle physiology.

Keywords: differentiation; division patterns; division-independent differentiation; hypertrophy; muscle stem cells; proliferation.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cell Differentiation*
  • Cell Division
  • Humans
  • Hypertrophy*
  • Muscle, Skeletal*
  • Satellite Cells, Skeletal Muscle* / metabolism
  • Satellite Cells, Skeletal Muscle* / physiology