Insights gained from computational modeling of YAP/TAZ signaling for cellular mechanotransduction

Hamidreza Jafarinia; Ali Khalilimeybodi; Jorge Barrasa-Fano; Stephanie I Fraley; Padmini Rangamani; Aurélie Carlier

doi:10.1038/s41540-024-00414-9

Insights gained from computational modeling of YAP/TAZ signaling for cellular mechanotransduction

NPJ Syst Biol Appl. 2024 Aug 15;10(1):90. doi: 10.1038/s41540-024-00414-9.

Authors

Hamidreza Jafarinia¹, Ali Khalilimeybodi², Jorge Barrasa-Fano³, Stephanie I Fraley⁴, Padmini Rangamani⁵, Aurélie Carlier⁶

Affiliations

¹ MERLN Institute for Technology-Inspired Regenerative Medicine, Department of Cell Biology-Inspired Tissue Engineering, Maastricht University, Maastricht, The Netherlands.
² Department of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, CA, 92093-0411, USA.
³ Department of Mechanical Engineering, Biomechanics Section, KU Leuven, Leuven, Belgium.
⁴ Department of Bioengineering, University of California San Diego, La Jolla, CA, 92093-0411, USA.
⁵ Department of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, CA, 92093-0411, USA. [email protected].
⁶ MERLN Institute for Technology-Inspired Regenerative Medicine, Department of Cell Biology-Inspired Tissue Engineering, Maastricht University, Maastricht, The Netherlands. [email protected].

Abstract

YAP/TAZ signaling pathway is regulated by a multiplicity of feedback loops, crosstalk with other pathways, and both mechanical and biochemical stimuli. Computational modeling serves as a powerful tool to unravel how these different factors can regulate YAP/TAZ, emphasizing biophysical modeling as an indispensable tool for deciphering mechanotransduction and its regulation of cell fate. We provide a critical review of the current state-of-the-art of computational models focused on YAP/TAZ signaling.

Publication types

Review

MeSH terms

Adaptor Proteins, Signal Transducing / metabolism
Animals
Computer Simulation*
Humans
Mechanotransduction, Cellular* / physiology
Models, Biological
Signal Transduction / physiology
Transcription Factors* / genetics
Transcription Factors* / metabolism
YAP-Signaling Proteins / metabolism

Substances

Transcription Factors
YAP-Signaling Proteins
Adaptor Proteins, Signal Transducing
YAP1 protein, human

Abstract

Publication types

MeSH terms

Substances

Grants and funding