Pd-catalyzed Markovnikov selective oxidative amination of 4-pentenoic acid

Chem Commun (Camb). 2024 Aug 29;60(71):9626-9629. doi: 10.1039/d4cc02504k.

Abstract

Pd-catalyzed regioselective amination of unactivated alkene remains a challenge and is of great interest. Herein, a palladium-catalyzed and ligand-controlled strategy for the Markovnikov selective oxidative amination of 4-pentenoic acid has been described. The protocol effectively reverses the carboxylic acid-directed anti-Markovnikov selectivity in oxidative amination of 4-pentenoic acid, successfully constructing γ-ketoamide derivatives.