Yellow nail syndrome in anti-SSA and anti-SSB positive primary Sjögren's syndrome

BMJ Case Rep. 2024 Aug 19;17(8):e260614. doi: 10.1136/bcr-2024-260614.

Abstract

Yellow nail syndrome (YNS) is a rare, acquired condition, characterised by at least two of the three clinical criteria: nail changes, respiratory tract disease and lymphoedema. Currently, the aetiology of YNS remains unknown; however, it is believed to be caused by impaired lymphatic drainage. Currently, there remain no definitive treatment options available and no prospective trials evaluating this. Management includes supportive care and symptomatic treatment. The presence of YNS has been described alongside various conditions, including autoimmune diseases, malignancies and drug exposures. To strengthen the literature on this topic, we present the case of a female patient with a history of anti-SSA and anti-SSB positive primary Sjögren's syndrome, who developed YNS in the immediate postpartum period.

Keywords: Rheumatology; Sjogren's syndrome.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies, Antinuclear / blood
  • Antibodies, Antinuclear / immunology
  • Female
  • Humans
  • Sjogren's Syndrome* / complications
  • Sjogren's Syndrome* / diagnosis
  • Sjogren's Syndrome* / drug therapy
  • Sjogren's Syndrome* / immunology
  • Yellow Nail Syndrome* / diagnosis

Substances

  • Antibodies, Antinuclear
  • SS-A antibodies