Multiciliogenesis: Tricking the cell-cycle machinery to build hundreds of cilia

Magdalena Maria Brislinger-Engelhardt; Peter Walentek

doi:10.1016/j.cub.2024.07.024

Multiciliogenesis: Tricking the cell-cycle machinery to build hundreds of cilia

Curr Biol. 2024 Aug 19;34(16):R786-R788. doi: 10.1016/j.cub.2024.07.024.

Authors

Magdalena Maria Brislinger-Engelhardt¹, Peter Walentek²

Affiliations

¹ Internal Medicine IV, Medical Center - University of Freiburg, CIBSS Centre for Integrative Biological Signalling Studies, and SGBM Spemann Graduate School for Biology and Medicine, University of Freiburg, Freiburg, Germany.
² Internal Medicine IV, Medical Center - University of Freiburg, CIBSS Centre for Integrative Biological Signalling Studies, and SGBM Spemann Graduate School for Biology and Medicine, University of Freiburg, Freiburg, Germany. Electronic address: [email protected].

PMID: 39163842
DOI: 10.1016/j.cub.2024.07.024

Abstract

Multiciliated cells produce over a hundred motile cilia anchored to the membrane by modified centrioles. Recent work has characterized an alternative cell cycle used by this post-mitotic cell type to generate additional centrioles without undergoing cell division.

MeSH terms

Animals
Cell Cycle* / physiology
Centrioles / metabolism
Centrioles / physiology
Cilia* / physiology