Fundamental research on germanium as the central element in compounds for bond activation chemistry and catalysis has achieved significant feats over the last two decades. Designing strategies for small molecule activations and the ultimate catalysts established capitalize on the orbital modalities of germanium, apparently imitating the transition-metal frontier orbitals. There is a growing body of examples in contemporary research implicating the tunability of the frontier orbitals through avant-garde approaches such as geometric constrained empowered reactivity, bimetallic orbital complementarity, cooperative reactivity, etc. The goal of this Perspective is to provide readers with an overview of the emerging opportunities in the field of germanium-based catalysis by perceiving the underlying key principles. This will help to convert the discrete set of findings into a more systematic vision for catalyst designs. Critical exposition on the germanium's frontier orbitals participations evokes the key challenges involved in innovative catalyst designs, wherein viewpoints are provided. We close by addressing the forward-looking directions for germanium-based catalytic manifold development. We hope that this Perspective will be motivational for applied research on germanium as a constituent of pragmatic catalysts.