OLAH connects fatty acid metabolism to the severity of respiratory viral disease

Cell. 2024 Aug 22;187(17):4549-4551. doi: 10.1016/j.cell.2024.07.032.

Abstract

Respiratory virus infections may cause profound respiratory illness, yet the factors that underlie disease severity are not well understood. In this issue of Cell, Jia, Crawford, et al.1 identify the role of oleoyl-ACP-hydrolase (OLAH) in mediating life-threatening inflammation associated with viral respiratory disease severity.

MeSH terms

  • Animals
  • Fatty Acids* / metabolism
  • Humans
  • Inflammation / metabolism
  • Mice
  • Respiratory Tract Infections / metabolism
  • Respiratory Tract Infections / virology

Substances

  • Fatty Acids