Abstract
The crosstalk between glioma cells and astrocytes plays a crucial role in developing temozolomide (TMZ) resistance of glioblastomas, together with the existence of the BBB contributing to the unsatisfactory clinical treatment of glioblastomas. Herein, we developed a borneol-modified and gastrodin-loaded liposome (Bo-Gas-LP), with the intent of enhancing the efficacy of TMZ therapy after intranasal administration. The results showed that Bo-Gas-LP improved GL261 cells' sensitivity to TMZ and prolonged survival of GL261-bearing mice by blocking the crosstalk between astrocytes and glioblastoma cells with the decrease of Cx43. Our study showed that intranasal Bo-Gas-LP targeting the crosstalk in glioblastoma microenvironments proposed a promising targeted therapy idea to overcome the current therapeutic limitations of TMZ-resistant glioblastomas.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Alkylating / pharmacology
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Antineoplastic Agents, Alkylating / therapeutic use
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Astrocytes* / drug effects
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Astrocytes* / metabolism
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Benzyl Alcohols* / chemistry
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Benzyl Alcohols* / pharmacology
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Benzyl Alcohols* / therapeutic use
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Brain Neoplasms / drug therapy
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Brain Neoplasms / metabolism
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Brain Neoplasms / pathology
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Cell Line, Tumor
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Connexin 43* / metabolism
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Down-Regulation* / drug effects
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Glioblastoma / drug therapy
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Glioblastoma / metabolism
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Glioblastoma / pathology
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Glioma / drug therapy
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Glioma / metabolism
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Glioma / pathology
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Glucosides* / chemistry
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Glucosides* / pharmacology
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Glucosides* / therapeutic use
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Humans
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Liposomes* / chemistry
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Mice
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Mice, Inbred C57BL
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Temozolomide* / pharmacology
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Temozolomide* / therapeutic use
Substances
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Temozolomide
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Glucosides
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Liposomes
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gastrodin
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Benzyl Alcohols
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Connexin 43
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Antineoplastic Agents, Alkylating