Effects of beta-hydroxybutyrate on rat embryos grown in culture

Experientia. 1985 Feb 15;41(2):273-5. doi: 10.1007/BF02002633.

Abstract

In order to investigate further the relationship between maternal diabetes and fetal malformation, rat embryos were grown in vitro in the presence of beta-hydroxybutyrate, one of the ketone bodies produced by diabetics. At 10 mM, beta-hydroxybutyrate produced minor abnormalities and at 20 mM it produced major abnormalities in rat embryos.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abnormalities, Drug-Induced / etiology*
  • Animals
  • Diabetic Ketoacidosis / complications*
  • Disease Models, Animal
  • Ectogenesis
  • Female
  • Hydroxybutyrates / toxicity*
  • Microscopy, Electron, Scanning
  • Pregnancy
  • Pregnancy in Diabetics / complications*
  • Rats

Substances

  • Hydroxybutyrates