Propionyl-CoA metabolism links chromatin acylation to cardiac transcription

Nat Cardiovasc Res. 2023 Dec;2(12):1109-1111. doi: 10.1038/s44161-023-00381-0. Epub 2023 Dec 4.

Abstract

The molecular mechanisms that link propionyl-CoA metabolism and epigenetic regulation of gene expression are unclear, as are the implications for heart function. Now, new insights into the modulation of chromatin acylation and transcription by aberrant oxidation of propionyl-CoA are revealed in the dysfunctional hearts of mice with propionic acidemia.

Publication types

  • News

MeSH terms

  • Acyl Coenzyme A* / metabolism
  • Acylation
  • Animals
  • Chromatin* / genetics
  • Chromatin* / metabolism
  • Epigenesis, Genetic
  • Mice
  • Myocardium / metabolism
  • Oxidation-Reduction
  • Propionic Acidemia / genetics
  • Propionic Acidemia / metabolism
  • Transcription, Genetic*

Substances

  • Acyl Coenzyme A
  • Chromatin
  • propionyl-coenzyme A