Innovations in Biosensor Technologies for Healthcare Diagnostics and Therapeutic Drug Monitoring: Applications, Recent Progress, and Future Research Challenges

Mohamed Hemdan; Mohamed A Ali; Ahmed S Doghish; Sherif S Abdel Mageed; Ibrahim M Elazab; Magdy M Khalil; Mostafa Mabrouk; Diganta B Das; Alaa S Amin

doi:10.3390/s24165143

Innovations in Biosensor Technologies for Healthcare Diagnostics and Therapeutic Drug Monitoring: Applications, Recent Progress, and Future Research Challenges

Sensors (Basel). 2024 Aug 8;24(16):5143. doi: 10.3390/s24165143.

Authors

Mohamed Hemdan¹, Mohamed A Ali¹, Ahmed S Doghish^{2

3}, Sherif S Abdel Mageed⁴, Ibrahim M Elazab⁵, Magdy M Khalil^{6

7}, Mostafa Mabrouk⁸, Diganta B Das⁹, Alaa S Amin¹⁰

Affiliations

¹ School of Biotechnology, Badr University in Cairo (BUC), Badr City 11829, Egypt.
² Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City 11829, Egypt.
³ Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Egypt.
⁴ Pharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City 11829, Egypt.
⁵ Department of Biochemistry, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt.
⁶ Medical Biophysics, Department of Physics, Faculty of Science, Helwan University, Cairo 11795, Egypt.
⁷ School of Applied Health Sciences, Badr University in Cairo (BUC), Badr City 11829, Egypt.
⁸ Refractories, Ceramics and Building Materials Department, National Research Centre, 33 El Bohouth St., Giza 12622, Egypt.
⁹ Department of Chemical Engineering, Loughborough University, Loughborough LE11 3TU, UK.
¹⁰ Chemistry Department, Faculty of Science, Benha University, Benha 13511, Egypt.

Abstract

This comprehensive review delves into the forefront of biosensor technologies and their critical roles in disease biomarker detection and therapeutic drug monitoring. It provides an in-depth analysis of various biosensor types and applications, including enzymatic sensors, immunosensors, and DNA sensors, elucidating their mechanisms and specific healthcare applications. The review highlights recent innovations such as integrating nanotechnology, developing wearable devices, and trends in miniaturisation, showcasing their transformative potential in healthcare. In addition, it addresses significant sensitivity, specificity, reproducibility, and data security challenges, proposing strategic solutions to overcome these obstacles. It is envisaged that it will inform strategic decision-making, drive technological innovation, and enhance global healthcare outcomes by synthesising multidisciplinary insights.

Keywords: biosensors; disease biomarker detection; healthcare applications; nanotechnology integration; therapeutic drug monitoring.

Publication types

Review

MeSH terms

Biomarkers / analysis
Biosensing Techniques* / methods
Delivery of Health Care
Drug Monitoring* / methods
Humans
Nanotechnology / methods
Wearable Electronic Devices

Substances

Biomarkers

Grants and funding

This research received no external funding.