Development and Validation of an Integrative Risk Score for Future Risk of Crohn's Disease in Healthy First-Degree Relatives: A Multicenter Prospective Cohort Study
Gastroenterology. 2025 Jan;168(1):150-153.e4.
doi: 10.1053/j.gastro.2024.08.021.
Epub 2024 Aug 30.
1 Division of Gastroenterology and Hepatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada.
2 Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Biostatistics Department, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Statistical Sciences, University of Toronto, Toronto, Ontario, Canada; Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada.
3 Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Biostatistics Department, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
4 Division of Gastroenterology and Hepatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada. Electronic address: [email protected].
5 Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada.
6 Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada.
7 Department of Cell & Systems Biology, and Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, Ontario.
8 University of Alberta, Edmonton, Alberta, Canada.
9 Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel, Faculty of Medicine, Tel Aviv University, Israel.
10 Pediatric Gastroenterology Unit, Sheba Medical Center, Tel-Hashomer, Israel.
11 Inflammatory Bowel Disease Clinic, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada.
12 Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada.
13 Canadian Gastro-Intestinal Epidemiology Consortium, Canada; British Columbia Children's Hospital, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
14 Hôpital Maisonneuve-Rosemont, Department of Medicine, University of Montreal, Montreal, Quebec, Canada.
15 Division of Gastroenterology, Hepatology & Nutrition, Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, Ontario, Canada.
16 Division of Gastroenterology, The Hospital for Sick Children, Toronto, Ontario, Canada.
17 The Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel.
18 University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre and, Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Manitoba, Winnipeg, Canada.
19 Departments of Medicine, Epidemiology, and Biostatistics University of Western Ontario, London, Ontario, Canada.
20 Department of Medicine, McMaster University, Farncombe Family Digestive Health Research Institute, Hamilton, Ontario, Canada.
21 Division of Gastroenterology, The Hospital for Sick Children, Toronto, Ontario, Canada; Genetics and Genome Biology, The Hospital for Sick Children Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
22 Division of Gastroenterology, Crohn's and Colitis Center, Department of Medicine, University of Miami, Miller School of Medicine, Miami, Florida.
23 Department of Medicine, Queens University, Kingston, Ontario, Canada.
24 Division of Gastroenterology, McGill University Health Centre, Montreal, Quebec, Canada.
25 Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
26 Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada.
27 Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
28 Department of Pediatrics, Memorial University, St. John's, NL, Canada.
29 Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
30 Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, Québec, Canada.
31 Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
32 Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
33 Connecticut Children's Medical Center Hartford, Connecticut.
34 Division of Gastroenterology, Memorial University of Newfoundland, St. John's, NL, Canada.
35 Department of Pediatrics, IWK Health, Dalhousie University, Halifax, Nova Scotia, Canada.