A subanalysis of Clostridium perfringens bloodstream infections from a 5-year retrospective nationwide survey (ITANAEROBY)

Anaerobe. 2024 Dec:90:102901. doi: 10.1016/j.anaerobe.2024.102901. Epub 2024 Aug 28.

Abstract

Clostridium perfingens bloodstream infections (BSIs) can be associated with high mortality rates. We performed a subanalysis of all C. perfringens BSIs enrolled during a multicentric retrospective observational study (ITANAEROBY). Data were collected from January 2016 to December 2020. C. perfringens BSIs were 134 (134/1960, 6.8 %). The highest resistance rate was observed for clindamycin (26/120, 21.6 %), penicillin (11/71, 15.4 %) and metronidazole (14/131, 10.7 %). In conclusion, C. perfringens reduced susceptibility phenotype to first-line therapy.

Keywords: Anaerobes; Antibiotic therapy; Bloodstream infections; Clostridium perfringens.

Publication types

  • Multicenter Study
  • Observational Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents* / pharmacology
  • Anti-Bacterial Agents* / therapeutic use
  • Bacteremia* / drug therapy
  • Bacteremia* / epidemiology
  • Bacteremia* / microbiology
  • Clostridium Infections* / epidemiology
  • Clostridium Infections* / microbiology
  • Clostridium perfringens* / drug effects
  • Clostridium perfringens* / genetics
  • Clostridium perfringens* / isolation & purification
  • Drug Resistance, Bacterial
  • Female
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Retrospective Studies

Substances

  • Anti-Bacterial Agents