Rapid brain lymphoma diagnostics through nanopore sequencing of cytology-negative cerebrospinal fluid

J Hench; C Hultschig; I Bratic Hench; H Sadasivan; Ö Yaldizli; G Hutter; S Dirnhofer; A Tzankov; S Frank

doi:10.1007/s00401-024-02793-z

Rapid brain lymphoma diagnostics through nanopore sequencing of cytology-negative cerebrospinal fluid

Acta Neuropathol. 2024 Sep 3;148(1):36. doi: 10.1007/s00401-024-02793-z.

Authors

J Hench¹, C Hultschig², I Bratic Hench², H Sadasivan³, Ö Yaldizli⁴, G Hutter⁵, S Dirnhofer², A Tzankov², S Frank²

Affiliations

¹ Institute for Pathology and Medical Genetics, University Hospital Basel, Basel, Switzerland. [email protected].
² Institute for Pathology and Medical Genetics, University Hospital Basel, Basel, Switzerland.
³ AI Group, AMD and Paul G Allen School of CSE, University of Washington, Seattle, USA.
⁴ Dept. of Neurology, University Hospital Basel, Basel, Switzerland.
⁵ Dept. of Neurosurgery, University Hospital Basel, Basel, Switzerland.

No abstract available

Keywords: CNS lymphoma; DNA methylation; Epigenetics; Liquid biopsy; Nanopore sequencing; Non-invasive diagnostics; Point-of-care testing; Rapid testing; Tumor classification; Unsupervised machine learning.

Publication types

Letter
Case Reports

MeSH terms

Aged
Brain Neoplasms* / cerebrospinal fluid
Brain Neoplasms* / diagnosis
Brain Neoplasms* / genetics
Brain Neoplasms* / pathology
Cytodiagnosis
Female
Humans
Lymphoma / cerebrospinal fluid
Lymphoma / diagnosis
Lymphoma / genetics
Lymphoma / pathology
Male
Middle Aged
Nanopore Sequencing / methods

Grants and funding

2023-F006/007/Stiftung für krebskranke Kinder, Regio Basiliensis