Cardiac involvement in eosinophilic granulomatosis with polyangiitis

Ugeskr Laeger. 2024 Aug 19;186(34):V02240141. doi: 10.61409/V02240141.
[Article in Danish]

Abstract

This case report describes a 40-year-old male patient with severe cardiac failure due to eosinophilic granulomatosis with polyangiitis (EGPA) and myocarditis. The fast diagnostic approach with cardiac MRI (CMR) and immunosuppressive treatment with glucocorticoid and cyclophosphamide near-normalized the patient's cardiac function. Myocarditis due to EGPA is rare, however life-threatening, so a systematic approach and early CMR should be considered in patients with known asthma presenting with eosinophilia and cardiac involvement.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Churg-Strauss Syndrome / complications
  • Churg-Strauss Syndrome / diagnosis
  • Churg-Strauss Syndrome / drug therapy
  • Cyclophosphamide / therapeutic use
  • Granulomatosis with Polyangiitis* / complications
  • Granulomatosis with Polyangiitis* / diagnosis
  • Granulomatosis with Polyangiitis* / drug therapy
  • Granulomatosis with Polyangiitis* / pathology
  • Heart Failure / drug therapy
  • Heart Failure / etiology
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Magnetic Resonance Imaging
  • Male
  • Myocarditis* / diagnosis
  • Myocarditis* / diagnostic imaging
  • Myocarditis* / drug therapy
  • Myocarditis* / etiology

Substances

  • Cyclophosphamide
  • Immunosuppressive Agents