Off-label uses of the Amplatzer Piccolo Occluder in children with congenital and acquired heart diseases

Future Cardiol. 2024;20(9):459-470. doi: 10.1080/14796678.2024.2355057. Epub 2024 Sep 5.

Abstract

Aim: The Amplatzer Piccolo Occluder (APO) is approved for patent ductus arteriosus (PDA) occlusion in infants weighing >700 g but could offer versatility to treat other lesions.Methods: Retrospective review of children in whom APO was utilized for defects other than PDA between January 2022 and June 2023.Results: The APO was used in nine patients; three for ventricular septal defects, four with coronary fistulas, one for a ventricular pseudoaneurysm and one where APO deployed within a fenestration of a previously placed Amplatzer Septal Occluder. All nine patients had successful occlusions without complications.Conclusion: The APO is a versatile device that can be used to treat various small diameter lesions in children besides the PDA for which it is currently approved for.

Keywords: Gerbode defect; amplatzer piccolo occluder; atrial septal defect; cardiac catheterization; congenital heart disease; coronary artery fistula; patent ductus arteriosus; pediatric cardiology; pediatric interventional cardiology; ventricular septal defect.

Plain language summary

[Box: see text].

MeSH terms

  • Adolescent
  • Cardiac Catheterization / methods
  • Child
  • Child, Preschool
  • Female
  • Heart Defects, Congenital / therapy
  • Heart Septal Defects, Ventricular / surgery
  • Heart Septal Defects, Ventricular / therapy
  • Humans
  • Infant
  • Male
  • Off-Label Use
  • Retrospective Studies
  • Septal Occluder Device*
  • Treatment Outcome