Emerging roles of hydrogen sulfide in colorectal cancer

Zhi-Liang Jiang; Yi Liu; Chuan-Hao Zhang; Ti Chu; Yi-Lun Yang; Yi-Wen Zhu; Yan Wang; Ya-Fang Liu; Yan-Xia Zhang; Zhi-Fen Feng; Xin-Ying Ji; Dong-Dong Wu

doi:10.1016/j.cbi.2024.111226

Emerging roles of hydrogen sulfide in colorectal cancer

Chem Biol Interact. 2024 Nov 1:403:111226. doi: 10.1016/j.cbi.2024.111226. Epub 2024 Sep 3.

Authors

Zhi-Liang Jiang¹, Yi Liu², Chuan-Hao Zhang¹, Ti Chu³, Yi-Lun Yang², Yi-Wen Zhu¹, Yan Wang³, Ya-Fang Liu², Yan-Xia Zhang³, Zhi-Fen Feng⁴, Xin-Ying Ji⁵, Dong-Dong Wu⁶

Affiliations

¹ Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, School of Stomatology, Henan University, Kaifeng, Henan, 475004, China; School of Clinical Medicine, Henan University, Kaifeng, Henan, 475004, China.
² Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, School of Stomatology, Henan University, Kaifeng, Henan, 475004, China; Kaifeng Key Laboratory of Periodontal Tissue Engineering, School of Stomatology, Henan University, Kaifeng, Henan, 475004, China.
³ Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, School of Stomatology, Henan University, Kaifeng, Henan, 475004, China.
⁴ School of Nursing and Health, Henan University, Kaifeng, Henan, 475004, China. Electronic address: [email protected].
⁵ Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, School of Stomatology, Henan University, Kaifeng, Henan, 475004, China; Department of Medicine, Huaxian County People's Hospital, Anyang, Henan, 456400, China; Center for Molecular Medicine, Faculty of Basic Medical Subjects, Shu-Qing Medical College of Zhengzhou, Zhengzhou, Henan, 450064, China. Electronic address: [email protected].
⁶ Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, School of Stomatology, Henan University, Kaifeng, Henan, 475004, China; Kaifeng Key Laboratory of Periodontal Tissue Engineering, School of Stomatology, Henan University, Kaifeng, Henan, 475004, China; Department of Stomatology, Huaihe Hospital of Henan University, Kaifeng, Henan, 475000, China. Electronic address: [email protected].

PMID: 39237072
DOI: 10.1016/j.cbi.2024.111226

Abstract

Hydrogen sulfide (H₂S), an endogenous gasotransmitter, plays a key role in several critical physiological and pathological processes in vivo, including vasodilation, anti-infection, anti-tumor, anti-inflammation, and angiogenesis. In colorectal cancer (CRC), aberrant overexpression of H₂S-producing enzymes has been observed. Due to the important role of H₂S in the proliferation, growth, and death of cancer cells, H₂S can serve as a potential target for cancer therapy. In this review, we thoroughly analyzed the underlying mechanism of action of H₂S in CRC from the following aspects: the synthesis and catabolism of H₂S in CRC cells and its effect on cell signal transduction pathways; the inhibition effects of exogenous H₂S donors with different concentrations on the growth of CRC cells and the underlying mechanism of H₂S in garlic and other natural products. Furthermore, we elucidate the expression characteristics of H₂S in CRC and construct a comprehensive H₂S-related signaling pathway network, which has important basic and practical significance for promoting the clinical research of H₂S-related drugs.

Keywords: Colorectal cancer; Endogenous gas transmitter; Hydrogen sulfide; Signal transduction.

Publication types

Review

MeSH terms

Animals
Cell Proliferation / drug effects
Colorectal Neoplasms* / drug therapy
Colorectal Neoplasms* / metabolism
Colorectal Neoplasms* / pathology
Humans
Hydrogen Sulfide* / metabolism
Signal Transduction* / drug effects

Substances

Hydrogen Sulfide